AAV Upstream Process Development Co-op

Intellia Therapeutics


Date: 1 week ago
City: Cambridge, MA
Contract type: Full time
Intellia Therapeutics

Why Join Intellia?




Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.





Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.





We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.





How You Will Achieve More At Intellia:



The AAV Upstream Process Development team is excited to welcome a co-op to the team from July – December 2023. In this role, you will have the opportunity to work both independently as well as part of the team to achieve platform development objectives. You will develop a diverse skill set in upstream process development including critical in-process analytical techniques in gene therapy. Through this experience, you will gain knowledge on recombinant AAV production platforms, recombinant AAV manufacturing challenges and optimization strategies as well as general drug product development processes in industrial settings.




Key responsibilities include:



  • Perform suspension HEK293 cell culture passage, as well as prepping, inoculating, transfecting, and harvesting shake flask/bioreactor vessels.


  • Perform AAV analytics including ELISA and ddPCR to support in-process analytics in PD’s activities.


  • Execute assigned experiments with minimal supervision.


  • Perform data analysis, translate data into findings and draw sound conclusions and present findings to a group of peers and area leaders.


  • Work cross-functionally with Downstream PD, AAV Core, and Analytical Development teams to facilitate sample processing and project execution


  • Contribute to maintaining and improving upon our safe, effective, and efficient lab operations





About You:



The ideal candidate is a motivated self-starter with high scientific integrity. You should be highly motivated and passionate to work in a fast-paced and growing environment and be a team player with an eye for continuous improvement. You will become acquainted with platform development strategy for upstream cell culture processes considering robustness, scalability and manufacturing feasibility/suitability. Additional role requirements include:



  • Undergraduate/Graduate student in Biological Engineering, Chemical Engineering, Biology, Biochemistry, or equivalent field


  • Basic knowledge of Microsoft Office applications (Word, PowerPoint, Excel)


  • Applicants must demonstrate the ability to work independently, take initiative, and complete tasks to deadlines without sacrificing quality of work




Meet your future team:



In this role, you will be part of the AAV Upstream Process Development team reporting to the Upstream lead and play a key role in platform fit, process optimization, scale-up and tech transfer for clinical manufacturing as well as late-stage activities such as process characterization. Your team is a part of the broader AAV Process Development organization, thus from this vantage point you will participate in and support multiple activities in the product development lifecycle and AAV PD team activities yet be a key member of a team accountable for upstream development workflow improvement. You will join the growing, collaborative and passionate Tech Ops team as we advance our therapeutic pipeline products using CRISPR genome-editing technologies. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.




This position is a fixed term Co-op opportunity with the following duration: July 2023 – December 2023. Candidates must be available 40 hours per week, Monday-Friday in Cambridge, MA.



Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.



EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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