Principal Associate Scientist, Protein Biomarkers - Cambridge - job 676240

Alnylam Pharmaceuticals, Inc.

Date: 04/08/2021

City: Cambridge, Massachusetts

Employment type: Full-time

Principal Associate Scientist


Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit for more information.

The ocular group within Research at Alnylam is seeking a highly motivated Principal Associate Scientist with experience in protein biomarkers (ligand binding assays) and cell culture to join our team to help advance novel RNAi programs from discovery to the clinic. The successful candidate will be technically skilled in a wide variety of ligand binding assays as well as in vitro systems, be a well-rounded scientist and bring diverse technical and analytical approaches to biological analysis. Previous experience in the ocular field and tissue imaging methods (example ISH and IHC) would be a plus.

Summary of Key Responsibilities

  • Develop ligand binding assays to enable protein biomarker work for ocular programs.

  • Identify novel biomarkers and validate assays to perform sample testing for Anlylam's ocular studies

  • Design, perform and analyze cell-based assays to help understand siRNA activity.

  • Help develop, advance and establish new in vitro systems to advance the ocular programs.

  • Design, execute experiments and perform data analysis, creating draft documents and presentations.

  • Present data to different groups within and outside of Research.

  • Help explore new technologies/ products and identify creative solutions to optimize current processes in a fast-paced environment.

  • Ability to troubleshoot and optimize new or existing assays.

  • Adapts well and exercises flexibility for changing platform needs, workflows and projects.


  • We require 6 years of research experience in an industrial (preferred) or academic setting working with protein biomarkers and cell based assays.

  • Excellent lab technique with the ability to analyze, interpret, and present data and work independently.

  • The candidate must thrive in a team environment and possess excellent communication skills (both written and oral). The role requires strong interpersonal skills, the capacity to multi-task, and the ability to function across teams. We particularly seek someone who is detail oriented and who will flourish in a goal-driven team environment under tight deadlines.

  • Candidates must have experience in each of the following areas:

  • Familiarity with in vitro and in vivo assays for pharmacokinetic and pharmacodynamic evaluations.

  • Purification and quantification of protein and tissue culture, experience with nucleic acids and tissue imaging techniques (example RNAscope) is a plus.

  • Experience with ocular diseases is preferred

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

How to apply:

To apply for this job you have to sign in to our website (My profile link in the header).

If you don't have an account with us yet, please Sign up.

Share you skills and get paid! All from the comfort of your home. Sign up for!