Computational Chemistry Lead - Boulder - job 676557

Cogent Biosciences

Date: 04/08/2021

City: Boulder, Colorado

Employment type: Full-time

Company Description

Precision therapeutics for genetically defined diseases. Real solutions for real challenges.

Who We Are

Cogent Biosciences is a biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent’s lead therapeutic candidate, CGT9486 (formerly known as PLX9486), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis which can severely impact many different tissues and organs in the body. We are also studying CGT9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling.

Job Description

We are growing!  This is one of a few roles that will help build out our research team to be located in Colorado.

We are looking for a leader in Computational Chemistry as we build out our research and discovery teams at Cogent Biosciences. In this opportunity you will be a thought leader our team will look to drive the science as we build out a strategic and robust pipeline.

What You Will Do:

You will be a leading member of the medicinal chemistry team, responsible for:

  • Working closely with a team of medicinal chemists, use an advanced computational chemistry platform to design small molecule drugs in an iterative process

  • Collaborate with structural biologists and team members to advance drug discovery projects

  • Lead computational chemistry support for new target identification

  • Participate in the selection of screening libraries, interpret screening results, and apply virtual screening techniques during the discovery process

  • Support desktop modeling tools for the scientific staff

  • Monitor and evaluate the completion of tasks and projects

  • In collaboration with our IT team, install, maintain, and support computational chemistry hardware and software


What You Bring:

  • Ph.D. in Chemistry, or equivalent experience

  • A minimum of 5 years’ experience working as a computational chemist on small molecule drug discovery projects in a Pharmaceutical or Biotech setting

  • Proven track record of accomplishments supported by publications and presentations

  • Working understanding across disciplines of a fully integrated drug discovery process from target identification to candidate selection

  • A passion for drug discovery and an excellent understanding of medicinal chemistry concepts

  • Experience with modern computational chemistry platforms such as Schrödinger or Chemical Computing Group

  • Strong oral and written communication skills, team-working and time-management skills

Additional Information


Our Locations

Cambridge, MA: Our Boston office is located within walking distance of the Alewife T station in Cambridge, MA. Our space includes an open office layout designed for collaboration. Free access is provided for both on-site parking and gym facilities in the building. We are in close proximity to leading academic institutions like MIT and Harvard and to potential pharmaceutical and biotech partners. This unique location allows for a high level of energy and intellectual exchange within and among fast growing early stage companies.

Boulder, CO: We are in the process of building a second location in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor.  Our CEO is based full-time in this location, which will serve as the future home of Cogent’s discovery research organization.

Our Offer To You

To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), unlimited time-off, a 401(k) plan, and commuter/parking benefits.

  • Cogent is an equal opportunity employer

  • Note to agencies – we are not accepting unsolicited resumes from agencies and will not be responsible for fees associated with any such submittals

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